Champions Manchester United will travel to Swansea City for their first Premier League match under new manager David Moyes, while Manuel Pellegrini's Manchester City are at home to Newcastle United on August 17.
United, kicking off their league campaign without Alex Ferguson in charge for the first time since 1986, were handed a tricky opening five matches in fixture lists published on Wednesday.
They host Chelsea, with Jose Mourinho back in charge for the second time, on August 24 before Moyes makes a return to Merseyside with a game at Anfield against old foes Liverpool on August 31.
The champions then take on promoted Crystal Palace before making the short journey to the Etihad Stadium for the first Manchester derby against last year's runners-up with their new Chilean manager on September 22.
The return Manchester derby at Old Trafford is scheduled for March 21.
"Lively start to the season! Let us at them," declared United defender Rio Ferdinand on Twitter.
Chelsea, third last season behind the Manchester clubs, start at Stamford Bridge against newly promoted Hull City with Frank Lampard hoping to make a record 18th appearance in an opening fixture of a Premier League season.
The west Londoners then host Aston Villa after their trip north to United.
Everton, with Roberto Martinez stepping into Moyes's shoes, start out at Norwich City before hosting Chelsea as